drug class

AMPK activator

activates AMP-activated protein kinase, the cell's energy-shortage sensor.

1 compound · filter the full catalogue by this class

ATX-304AMPK activator
ATX-304, formerly O304, is a pan-AMPK activator from Betagenon developed as a type 2 diabetes drug and exercise mimetic. In a phase IIa trial in people with type 2 diabetes already on metformin, it lowered fasting glucose and insulin resistance and improved microvascular perfusion. Newer mouse work extends it to fatty liver and kidney injury. The developer's patents describe a milled sodium salt: in volunteers, a quarter of the dose matched the blood levels of the original suspension, partly because of the salt and partly because of the milling.
Early human trials