NNMT inhibitor
blocks nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide and removes it from NAD+ recycling.
2 compounds · filter the full catalog by this class
- 5-Amino-1MQNNMT inhibitor
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that is more active in the fat and liver of obese mice. In obese mice, injections reduced body weight and fat without lowering food intake. In old mice they improved muscle repair and grip strength. No study has given it to people, and nearly all of the published work comes from one group linked to the company developing it.
Preclinical - JBSNF-000088NNMT inhibitor
JBSNF-000088 (6-methoxynicotinamide) is an experimental inhibitor of nicotinamide N-methyltransferase (NNMT). Oral treatment reduced weight gain and improved glucose handling in diet-induced obese mice, but it did not reduce weight in two genetic obesity models. Its published evidence is preclinical; no human dose, efficacy or safety has been established.
Preclinical