drug class

NNMT inhibitor

blocks nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide and removes it from NAD+ recycling.

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5-Amino-1MQNNMT inhibitor
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that is more active in the fat and liver of obese mice. In obese mice, injections reduced body weight and fat without lowering food intake. In old mice they improved muscle repair and grip strength. No study has given it to people, and nearly all of the published work comes from one group linked to the company developing it.
Preclinical