NAD+ booster
raises cellular NAD+, by supplying a precursor or by slowing the enzymes that use it up or divert its building blocks.
2 compounds · filter the full catalogue by this class
- 5-Amino-1MQNNMT inhibitor
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that is more active in the fat and liver of obese mice. In obese mice, injections reduced body weight and fat without lowering food intake. In old mice they improved muscle repair and grip strength. No study has given it to people, and nearly all of the published work comes from one group linked to the company developing it.
Preclinical - NAD+Coenzyme
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell. It carries electrons in energy metabolism and is used up by sirtuins, PARPs and CD38. Clinics sell it as an intravenous drip, but no trial has tested NAD+ infusions for any health outcome. In a small study, infused NAD+ disappeared from the blood for the first 2 hours. Most human data come from its oral precursors NR and NMN. They reliably raise NAD+, but their effects on health outcomes are mixed and often null.
Early human trials