ERR agonist
activates the estrogen-related receptors (ERRα/β/γ) that drive mitochondrial and oxidative genes.
2 compounds · filter the full catalog by this class
- SLU-PP-332ERR agonist
SLU-PP-332 is a synthetic agonist of all three estrogen-related receptors (ERRα, β and γ), strongest at ERRα, and the best-known "exercise mimetic" research compound. In mice it switched on an aerobic exercise gene program, increased oxidative muscle fibers and improved endurance. In obese mice it raised energy expenditure and fat oxidation, reduced fat mass and improved glucose tolerance. It has never been tested in humans.
Preclinical - SLU-PP-915ERR agonist
SLU-PP-915 is a pan-ERR agonist from the lab that made slu-pp-332. It is a chemically distinct thiophene boronic acid and, unlike SLU-PP-332, it is orally bioavailable. In mice it improved aerobic exercise performance as much as SLU-PP-332 did and protected the heart in a heart-failure model. It has never been tested in humans.
Preclinical