Skip to content
superstack

slow-build memory

three compounds that take weeks, aimed at memory rather than today's focus

  1. botanical extract
    Bacopa monnieri
    the memory herb; around 12 weeks to show
    Human RCTs
  2. Creatine
    brain energy buffer
    Established
  3. Citicoline
    membrane and choline supply
    Human RCTs

Read from the entries

computed from each compound's own data at build; nothing here is typed in

Conflictsnot documented

3 pairs read: 3 not documented.

  • Bacopa monnieri + Creatine
  • Bacopa monnieri + Citicoline
  • Creatine + Citicoline
Overlap

No shared class or direct target: each item pulls a different lever.

Shared effects
  • Memory3 of 3
  • Attention3 of 3
Evidence floor

A stack is only as well supported as its weakest item.

Human RCTs

set by Bacopa monnieri, Citicoline

  • Bacopa monnieri4 papers
    2008 · RCT · Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.2010 · RCT · Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial.2014 · meta-analysis · Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.2021 · meta-analysis · The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data.
  • Creatine5 papers
    2021 · review · Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?2023 · meta-analysis · Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials.2024 · meta-analysis · The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.2024 · clinical trial · Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.2025 · meta-analysis · Effect of creatine supplementation on kidney function: a systematic review and meta-analysis.
  • Citicoline5 papers
    1991 · clinical trial · A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia.2002 · review · Citicoline: neuroprotective mechanisms in cerebral ischemia.2014 · RCT · Improvements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage.2020 · meta-analysis · Application of Citicoline in Neurological Disorders: A Systematic Review.2023 · meta-analysis · Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis.

Why it works

Nothing in this stack is felt on the day you take it. Bacopa monnieri improved verbal learning and recall after about 12 weeks in randomised trials [1]. Creatine shows modest memory gains in meta-analysis, largest in older adults [2]. Citicoline's evidence is mainly in cognitive decline [3].

Worth knowing

The evidence floor card shows where this stack is weakest. Each compound's support comes from a different population, and none of the three combinations has been studied.

References

  1. [1]
  2. [2]
    Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials.
    Prokopidis K, Giannos P, Triantafyllidis KK et al.Nutr Rev 2023meta-analysis · humanPMID 35984306◌ unreviewed
  3. [3]
    Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis.
    Bonvicini M, Travaglini S, Lelli D et al.Nutrients 2023meta-analysis · humanPMID 36678257◌ unreviewed

Not a protocol and not a recommendation to combine anything. Read the individual entries, and talk to a clinician before taking any of this, particularly anything labelled prescription drug.