drug class

Mitochondrial uncoupler

lets protons leak across the mitochondrial membrane so fuel is burned without making ATP.

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BAM15Mitochondrial uncoupler
BAM15 is a mitochondrial uncoupler. It lets protons leak back into mitochondria so fuel is burned without making ATP, and unlike older uncouplers it does not depolarise the cell's outer membrane. In obese mice it reduced fat mass and improved insulin sensitivity without changing food intake, lean mass or body temperature. It has not been tested in humans.
Preclinical