Mineral

Lithium orotate is a lithium salt sold over the counter as a low-dose supplement, far below the doses of prescription lithium carbonate. Interest rose after a 2025 Nature study that restored brain lithium with lithium orotate in mice and prevented Alzheimer-like changes. There are no controlled human trials of lithium orotate itself. Whether the orotate salt behaves differently from other lithium salts is disputed.

Magnesium is an essential mineral sold in many salt forms. Meta-analyses of randomised trials find modest drops in blood pressure, largest in people with hypertension or low magnesium. They also find improved insulin resistance with longer use and fewer migraine attacks. Evidence for sleep and depression is weaker but positive. Which salt matters less than marketing suggests.