indole-ring amines such as serotonin and melatonin.
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Melatonin is the hormone the pineal gland releases at night to signal darkness. Taken as a supplement, its most convincing use is jet lag, where a Cochrane review put the number needed to treat at 2. For insomnia the benefit is real but modest: about 7 minutes faster sleep onset and 8 minutes more sleep on average. Timing matters as much as dose.