Polyunsaturated fatty acid

Fish oil supplies the two long-chain marine omega-3 fatty acids EPA and DHA. Its best-established effect is on triglycerides: high-quality evidence puts the reduction at roughly 15%, dose-dependently, and prescription formulations at 4 g a day are licensed drugs for severe hypertriglyceridaemia. What it does not do is what most people buy it for. A Cochrane review of 79 trials in 112,059 people found little or no effect of EPA and DHA on all-cause mortality, cardiovascular mortality or cardiovascular events, and the three largest modern supplement trials — VITAL, ASCEND and STRENGTH — were all null.